Clinical Signs

Signs of Neuropathy:

Neuropathic pain can be confirmed by demonstrating physical signs and symptoms;   features of nerve dysfunction in the painful area, as well as at the corresponding spinal level.  These signs outperform laboratory tests and are frequently more sensitive than radiological investigations. Neuropathic conditions may present with or without a history of injury,will be treatment resistant, and last longer than the period of normal tissue healing.

Dr. Gunn’s Radiculopathy Model outlines these neuropathic features below:

Sensory Alteration:

  • The painful area is tender to finger pressure. Tenderness is maximal over motor points where the nerve enters a muscle or tendon. These generally correspond to acupuncture and trigger points.
  • Sometimes multiple tender points occur when more than one spinal segment is involved, which is known as fibromyalgia.
  • Tenderness can also be located in the spinal muscles.

 Autonomic Features:

  • The painful part is usually colder (from vasoconstriction).
  • The painful area may exhibit excess perspiration.
  • There may be Goosebumps over the painful area.
  • Often there is excess fluid in the subcutaneous tissues, as in Trophedema:
  • The Matchstick Test
  • The Skin Rolling Test
Orange Peel
Matchstick Test
Skin Rolling Test


Internal Organs:

Peripheral nerves innervate internal organs. Neuropathy in these autonomic nerves often go unsuspected and undetected. The following conditions give strong indications of neuropathic origin: irritable bowel syndrome and adult respiratory distress syndrome (ARDS).

Trophic Changes (due to reduced neural stimulation):

  • Localized hair loss
  • Brittle Nails
  • Psoriasis (Abnormal skin)

Muscle/Motor Abnormalities:

    • The most important and widespread features of neuropathic pain.
    • Changes within muscle can be extremely painful (supersensitive nerve receptors in muscle).
    • Shortened muscles can produce mechanical pain by pulling on tendons and joints.

        • The most crucial shortening occurs in paraspinal muscles across a joint space, compressing the disc and sometimes the nerve root. The significance: neuropathy becomes the primary condition, and the ‘root signs’ are secondary results.
        • Muscle shortening
        • Muscle contracture
        • Shortened paraspinal muscles
        • Facet Joint Syndrome